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pentobarbital will minimize the extent or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will increase effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Warning/Watch. Coadministration of ifosfamide with CYP2B6 inducers may perhaps boost metabolism of if